Anti-D immunoglobulin in children with newly diagnosed immune thrombocytopenic purpura: a pilot study.

نویسندگان

  • P M Monteleone
  • M A Vander Heyden
  • D A Steele
  • J F Kelleher
چکیده

1. Angelini A, Dragani A, Berardi A, Iacone A, Fioritoni G, Tortolano G. Evaluation of four different methods for platelet freezing. In vitro and in vivo studies. Vox Sang 1992; 62:146-51. 2. Currie LM, Livesey SA, Harper JR, Connor J. Cryopreservation of single-donor platelets with a reduced dimethyl sulfoxide concentration by addition of second-messenger effectors: enhanced retention of in vitro activity. Transfusion 1998; 38:160-7. 3. Currie LM, Lichtiger B, Livesey SA, Tansey W, Yang DJ, Connor J. Enhanced circulatory parameters of human platelets cryopreserved with second-messenger effectors: an in vivo study of 16 volunteer platelet donors. Br J Haematol 1999; 105:826-31. 4. Vadhan-Raj S, Currie LA, Bueso-Ramos C, Livesey SA, Connor J. Enhanced retention of in vitro activity of platelets from recombinant human thrombopoietintreated patients following long-term cryopreservation with platelet-preserving solution (ThromboSol®) and 2% DMSO. Br J Haematol 1999; 104:403-11. 5. Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgaard RA. Description of an in vitro platelet function analyzer-PFA100TM. Semin Thromb Hemost 1995; 21(Suppl 2):106-12. 6. Favaloro EJ, Facey D, Henniker A. Use of a novel platelet function analyzer (PFA-100TM) with high sensitivity to disturbances in von Willebrand factor to screen for von Willebrand’s disease and other disorders. Am J Hematol 1999; 62:165-74. 7. Mammen EF, Comp PC, Gosselin R, et al. PFA-100TM system: a new method for assessment of platelet dysfunction. Semin Thromb Hemost 1998; 24:195-202. 8. Rand ML, Carcao MD, Blanchette VS. Use of the PFA100® in the assessment of primary, platelet-related hemostasis in a pediatric setting. Semin Thromb Hemost 1998; 24:523-9. 9. Borzini P, Lazzaro A, Mazzucco L. Evaluation of the hemostatic function of stored platelet concentrates using the platelet function analyser (PFA-100TM). Haematologica 1999; 84:1104-9. Anti-D immunoglobulin in children with newly diagnosed immune thrombocytopenic purpura: a pilot study

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Comparison of anti-D immunoglobulin and dexamethasone in chronic and persistent forms of pediatric immune thrombocytopenic purpura

Bakcground: The aim of ITP treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. This study was conducted with the objective of comparing the efficacy of anti-D immunoglobulin (Ig) with dexamethasone in treating childhood ITP. Materials and Methods: In this randomized prospective control trial, 20 ITP patients (Platelet count<20,000/&micro;l) younger than...

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Comparison of Anti-D Immunoglobulin and Dexamethasone in Chronic and Persistent Forms of Pediatric Immune Thrombocytopenic Purpura

Bakcground: The aim of ITP treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. This study was conducted with the objective of comparing the efficacy of anti-D immunoglobulin (Ig) with dexamethasone in treating childhood ITP. Materials and Methods: In this randomized prospective control trial, 20 ITP patients (Platelet count<20,000/&micro;l) younger th...

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Efficacy and safety of anti-D for immune thrombocytopenic purpura in children.

This study was conducted in 20 children (16 males) (mean age 9.2 +/- 4.34y) with immune thrombocytopenic purpura (ITP) to assess the response to anti-D immunoglobulin. Six patients had newly diagnosed ITP, 6 had persistent ITP and 8 had chronic ITP. The overall response rate was 70% (14/20). The median time to response was 3 days (1-13 days). Response to anti-D was not related to age, sex, seve...

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Clinical Features and Treatment Outcomes of Primary Immune Thrombocytopenic Purpura in Hospitalized Children Under 2-Years Old

Abstract Background Immune thrombocytopenic purpura (ITP)&nbsp;is the most prevalent cause of&nbsp;thrombocytopenia in children. Despite the&nbsp;importance of ITP in children under 2-&nbsp;years old, only a few publications are&nbsp;available in the literature. ITP usually&nbsp;presents itself as &nbsp; isolated&nbsp;thrombocytopenia and mucocutaneous&nbsp;bleeding. Materials and Methods T...

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Intravenous immune globulin versus intravenous anti-D immune globulin for the treatment of acute immune thrombocytopenic purpura.

OBJECTIVE The purpose of this study was to compare the efficacy and side effects of intravenous immunoglobulin (IVIG) with intravenous anti-D immunoglobulin for treatment of newly diagnosed acute childhood Idiopathic thrombocytopenic purpura (ITP). METHODS Children (6 months to 14 years) with newly diagnosed acute ITP and platelet count below 20,000/ microL were randomized to receive single d...

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Neutropenia Following Intravenous Immunoglobulin Therapy in Pediatric Patients with Idiopathic Thrombocytopenic Purpura

Background: Children with idiopathic thrombocytopenic purpura who are treated with intravenous immunoglobulin therapy might experience a decline in their absolute neutrophil count. The aim of this study was to investigate the incidence of neutropenia following intravenous immunoglobulin therapy in children with idiopathic thrombocytopenic purpura undergoing intravenous immunoglobulin therapy. ...

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عنوان ژورنال:
  • Haematologica

دوره 85 8  شماره 

صفحات  -

تاریخ انتشار 2000